Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry
| Autor: | Masaki Okumura, Young-Ho Lee, Yuxi Lin, Natalia Markova, Itoh Dai, John E. Ladbury, Misaki Kinoshita, Fabio Sterpone |
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| Přispěvatelé: | Laboratoire de biochimie théorique [Paris] (LBT (UPR_9080)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Osaka University [Osaka], Université Paris Diderot - Paris 7 (UPD7)-Institut de biologie physico-chimique (IBPC), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Amyloid Kinetics Calorimetry Microscopy Atomic Force Catalysis 03 medical and health sciences Materials Chemistry [CHIM]Chemical Sciences ComputingMilieux_MISCELLANEOUS Calorimetry Differential Scanning Beta-2 microglobulin Chemistry technology industry and agriculture Metals and Alloys Energy landscape Isothermal titration calorimetry General Chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry 030104 developmental biology Amyloid aggregation Ceramics and Composites Biophysics Thermodynamics beta 2-Microglobulin |
| Zdroj: | Chemical Communications Chemical Communications, Royal Society of Chemistry, 2018, 54 (57), pp.7995-7998. ⟨10.1039/c8cc02718h⟩ |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/c8cc02718h⟩ |
| Popis: | Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of β2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects. |
| Databáze: | OpenAIRE |
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