Folic acid administration reduces neointimal thickening, augments neo-vasa vasorum formation and reduces oxidative stress in saphenous vein grafts from pigs used as a model of diabetes
| Autor: | Gianni D Angelini, Frank C T Smith, Jamie Y. Jeremy, Nilima Shukla, Jwj Bloor |
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| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Neointima medicine.medical_specialty Homocysteine Swine Endocrinology Diabetes and Metabolism Type 2 diabetes medicine.disease_cause Statistics Nonparametric Article Diabetes Mellitus Experimental chemistry.chemical_compound Folic Acid Diabetes mellitus Internal medicine Internal Medicine medicine Animals Saphenous Vein Vascular Patency Analysis of Variance business.industry Vasa Vasorum medicine.disease Tunica intima Pathophysiology Oxidative Stress Carotid Arteries Endocrinology medicine.anatomical_structure chemistry Vasa vasorum cardiovascular system Endothelium Vascular Tunica Intima business Oxidative stress |
| Zdroj: | Diabetologia. 53:980-988 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | There is evidence that plasma homocysteine augments vein graft failure and that it augments both micro- and macro-angiopathy in patients with diabetes mellitus. It is therefore suggested that homocysteine may augment vein graft thickening, a major cause of vein graft failure, in diabetic patients, as well as impairing adaptive growth of a new vasa vasorum, possibly through overproduction of superoxide. In order to test these proposals, the effect of folic acid administration, which lowers plasma homocysteine, on vein graft thickening and microvessel density was studied in pigs used as a model of diabetes.Non-ketotic hyperglycaemia was induced in Landrace pigs by intravenous injection of streptozotocin, and folic acid was fed daily for 1 month. Vein grafts were excised and the thickness of the neointima and media and microvessel density were assessed by planimetry and superoxide formation.Plasma total homocysteine was significantly reduced by folic acid in both control and diabetic pigs, whereas glucose was unchanged. Compared with controls, diabetic pigs showed increased neointimal thickness and superoxide formation and decreased adventitial microvessel density. Folic acid reduced neointimal thickness and superoxide formation and augmented microvessel density in diabetic but not in control pigs.Folic acid administration reduces neointimal thickening, augments vasa vasorum neoformation and reduces oxidative stress in saphenous vein grafts from diabetic pigs. Folic acid may therefore be particularly effective in reducing vein graft failure in diabetic patients. |
| Databáze: | OpenAIRE |
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