Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-c]isoquinolines and Related Heterocycles

Autor:	Adel M. Kamal El-Dean, Asmaa S. A. Sayed, Shaban M. Radwan, Remon M. Zaki
Rok vydání:	2019
Předmět:	General Chemical Engineering General Chemistry Carbon-13 NMR Antimicrobial Medicinal chemistry Article Chemistry chemistry.chemical_compound Acetic acid Chloroacetone chemistry Proton NMR Moiety Ethyl chloroacetate Chloroacetamide QD1-999
Zdroj:	ACS Omega ACS Omega, Vol 5, Iss 1, Pp 252-264 (2019)
ISSN:	2470-1343
Popis:	A novel series of 1-amino-2-substituted-5-piperidinyl-6,7,8,9-tertahydrothieno[2,3-c]isoquinolines (4a–e) was synthesized upon treatment of 4-cyano-1-piperidinyl-5,6,7,8-tetrahydroisoquinline-3(2H)-thione (2) with α-halo carbonyl compounds such as chloroacetone, ethyl chloroacetate, 2-bromoacetophenone, chloroacetamide, and chloroacetanilide. Construction the pyrrolyl ring associated with the thienotetrahydroisoquinoline moiety was achieved by treatment of compounds 4a, b with 2,5-dimethoxytertahydrofuran in acetic acid. 1-Pyrrolyl-2-substituted-thieno[2,3-c]isoquinolines 5a and 5b which in turn were used as multipurpose precursors for synthesis of other new heterocycles. Assignments of the chemical structures of the respectively synthesized thienotetrahydroisoquinolines and their derivatives were established on the bases of elemental and spectral techniques (Fourier transform infrared, 1H NMR, 13C NMR, and mass spectroscopy). Furthermore, certain compounds were screened for their antimicrobial activity which revealed promising activities against various pathogenic strains of bacteria and fungi.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c95a605e5b1165218ab24f6d66ceac0 https://doi.org/10.1021/acsomega.9b02604 Zobrazit plný text záznamu