Pseudo‐Enhancement in Intracranial Aneurysms on Black‐Blood MRI : Effects of Flow Rate, Spatial Resolution, and Additional Flow Suppression
| Autor: | Naomi Larsen, Franziska Gaidzik, Olav Jansen, Rafael Medero, Carson Hoffman, Philipp Berg, Michael A. Speidel, Lindsay E. Bodart, Jan-Bernd Hövener, Mariya S. Pravdivtseva, Kevin M. Johnson, Oliver Wieben, Leonardo A. Rivera-Rivera, Alejandro Roldán-Alzate |
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| Rok vydání: | 2021 |
| Předmět: |
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Lumen (anatomy) computer.software_genre Signal Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Aneurysm Nuclear magnetic resonance Flip angle Voxel medicine Humans Contrast (vision) Radiology Nuclear Medicine and imaging Prospective Studies Image resolution media_common business.industry Intracranial Aneurysm medicine.disease Magnetic Resonance Imaging Black or African American Flow (mathematics) business computer Magnetic Resonance Angiography |
| Zdroj: | J Magn Reson Imaging |
| ISSN: | 1522-2586 1053-1807 |
| Popis: | BACKGROUND Vessel-wall enhancement (VWE) on black-blood MRI (BB MRI) has been proposed as an imaging marker for a higher risk of rupture and associated with wall inflammation. Whether VWE is causally linked to inflammation or rather induced by flow phenomena has been a subject of debate. PURPOSE To study the effects of slow flow, spatial resolution, and motion-sensitized driven equilibrium (MSDE) preparation on signal intensities in BB MRI of patient-specific aneurysm flow models. STUDY TYPE Prospective. SUBJECTS/FLOW ANEURYSM MODEL/VIRTUAL VESSELS Aneurysm flow models based on 3D rotational angiography datasets of three patients with intracranial aneurysms were 3D printed and perfused at two different flow rates, with and without Gd-containing contrast agent. FIELD STRENGTH/SEQUENCE Variable refocusing flip angle 3D fast-spin echo sequence at 3 T with and without MSDE with three voxel sizes ((0.5 mm)3 , (0.7 mm)3 , and (0.9 mm)3 ); time-resolved with phase-contrast velocity-encoding 3D spoiled gradient echo sequence (4D flow MRI). ASSESSMENT Three independent observers performed a qualitative visual assessment of flow patterns and signal enhancement. Quantitative analysis included voxel-wise evaluation of signal intensities and magnitude velocity distributions in the aneurysm. STATISTICAL TESTS Kruskal-Wallis test, potential regressions. RESULTS A hyperintense signal in the lumen and adjacent to the aneurysm walls on BB MRI was colocalized with slow flow. Signal intensities increased by a factor of 2.56 ± 0.68 (P |
| Databáze: | OpenAIRE |
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