T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

Autor: Sanjiv A. Luther, Kai-Michael Toellner, Richard K.-W. Choy, Daniel Man-Yuen Sze, Hans Acha-Orbea, Dale R. Taylor, Ian C. M. MacLennan
Rok vydání: 1998
Předmět:
T cell
Immunology
Plasma Cells
Priming (immunology)
chemical and pharmacologic phenomena
Biology
Lymphocyte Activation
Bordetella pertussis
Article
Interleukin 21
Interferon-gamma
Mice
Th2 Cells
medicine
Immunology and Allergy
Cytotoxic T cell
Animals
B cell
Interleukin 4
Mice
Inbred BALB C
Vaccination
Germinal center
Articles
Th1 Cells
Germinal Center
Molecular biology
Immunoglobulin Class Switching
medicine.anatomical_structure
Immunoglobulin class switching
Mammary Tumor Virus
Mouse
Bordetella pertussis/immunology
Germinal Center/immunology
Haptens/immunology
Interferon-gamma/biosynthesis
Interleukin-4/biosynthesis
Lymph Nodes/cytology
Lymph Nodes/immunology
Mammary Tumor Virus
Mouse/immunology
Spleen/cytology
Spleen/immunology
gamma-Globulins/immunology
Interleukin-4
Lymph Nodes
gamma-Globulins
Haptens
Spleen
Zdroj: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 187, no. 8, pp. 1193-1204
ISSN: 0022-1007
Popis: The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cγ2a and Cγ1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon γ in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten–protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten–protein can proceed in a node where there is substantial Th1 activity.
Databáze: OpenAIRE
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