HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
| Autor: | Castellsagué, Xavier, Alemany, Laia, Quer, Miquel, Halec, Gordana, Quirós, Beatriz, Tous, Sara, Clavero, Omar, Alòs, Llúcia, Biegner, Thorsten, Szafarowski, Tomasz, Alejo, Maria, Holzinger, Dana, Cadena, Enrique, Claros, Edith, Hall, Gillian, Laco, Jan, Poljak, Mario, Benevolo, Maria, Kasamatsu, Elena, Mehanna, Hisham, Ndiaye, Cathy, Guimerà, Núria, Lloveras, Belen, Leon, Xavier, Ruiz-Cabezas, Juan, Alvarado-Cabrero, Isabel, Kang, Chang-Suk, Oh, Jin-Kyoung, Garcia-Rojo, Marc, Iljazovic, Ermina, Ajayi, Oluseyi F., Duarte, Flora, Nessa, Ashrafun, Tinoco, Leopoldo, Duran-Padilla, Marc, Pirog, Edyta, Viarheichyk, Halina, Morales, Hesler, Costes, Valérie, Félix, Ana, Germar, Maria Julieta V., Mena, Marisa, Ruacan, Arzu, Jain, Asha, Mehrotra, Ravi, Goodman, Marc, Lombardi, Luis Estuardo, Ferrera, Annabelle, Malami, Sani, Albanesi, Estela, Dabed, Pablo, Molina, Carla, López-Revilla, Rubén, Mandys, Václav, González, Manuel, Velasco, Julio, Bravo, Ignacio, Quint, Wim, Pawlita, Michael, Muñoz, Nubia, Sanjosé, Silvia de, Bosch, F. Xavier, Study Group, ICO International HPV in Head and Neck Cancer |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Larynx Cancer Research Pathology International Cooperation 0302 clinical medicine Cyclin D1 Papillomaviridae Human papillomavirus 16 biology virus diseases Middle Aged Immunohistochemistry female genital diseases and pregnancy complications Salivary Proline-Rich Proteins 3. Good health Oropharyngeal Neoplasms Oropharyngeal Neoplasm medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Adult medicine.medical_specialty Genotype [SDV.CAN]Life Sciences [q-bio]/Cancer 03 medical and health sciences Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Carcinoma Humans Cyclin-Dependent Kinase Inhibitor p16 Aged Papillomavirus Infections Head and neck cancer Pharynx biology.organism_classification medicine.disease Cross-Sectional Studies 030104 developmental biology DNA Viral Attributable risk Etiology Tumor Suppressor Protein p53 |
| Zdroj: | JNCI: Journal of the National Cancer Institute JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2016, 108 (6), pp.djv403. ⟨10.1093/jnci/djv403⟩ JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0027-8874 1460-2105 |
| DOI: | 10.1093/jnci/djv403⟩ |
| Popis: | Background: We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. Methods: Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection. Samples containing HPV-DNA were further subject to HPV E6*I mRNA detection and to p16(INK4a), pRb, p53, and Cyclin D1 immunohistochemistry. Final estimates of HPV-AFs were based on HPV-DNA, HPV E6*I mRNA, and/or p16(INK4a) results. Results: A total of 3680 samples yielded valid results: 1374 pharyngeal, 1264 OC, and 1042 laryngeal cancers. HPV-AF estimates based on positivity for HPV-DNA, and for either HPV E6* I mRNA or p16(INK4a), were 22.4%, 4.4%, and 3.5% for cancers of the oropharynx, OC, and larynx, respectively, and 18.5%, 3.0%, and 1.5% when requiring simultaneous positivity for all three markers. HPV16 was largely the most common type. Estimates of HPV-AF in the oropharynx were highest in South America, Central and Eastern Europe, and Northern Europe, and lowest in Southern Europe. Women showed higher HPV-AFs than men for cancers of the oropharynx in Europe and for the larynx in Central-South America. Conclusions: HPV contribution to HNCs is substantial but highly heterogeneous by cancer site, region, and sex. This study, the largest exploring HPV attribution in HNCs, confirms the important role of HPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs. |
| Databáze: | OpenAIRE |
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