TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder
| Autor: | Ziru Liu, Meigui Chen, Qiong Zou, Lufeng Liang, Yuan Yuan, Jinghe Li, Dongcai Liu, Zhulin Yang, Daiqiang Li, Senlin Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
squamous cell carcinoma
Cancer Research Pathology medicine.medical_specialty Adenosquamous carcinoma adenosquamous carcinoma Metastasis gallbladder cancer Biopsy Medicine metastasis Gallbladder cancer PEG10 adenocarcinoma medicine.diagnostic_test Oncogene business.industry Gallbladder Cancer Articles medicine.disease medicine.anatomical_structure TSG101 Oncology Adenocarcinoma prognosis business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and paternally expressed gene (PEG) 10 was assessed in 46 SC/ASCs and 80 adenocarcinomas (ACs) using immunohistochemistry, and the samples were further analyzed to examine correlations with the clinicopathological characteristics. It was demonstrated that positive TSG101 and PEG10 expression were significantly associated with large tumor size, high tumor-node-metastasis (TNM) stage, lymph node metastasis, invasion and no resection (only biopsy) of SC/ASC and AC. The univariate Kaplan-Meier analysis showed that positive TSG101 and PEG10 expression, and differentiation, tumor size, TNM stage, lymph node metastasis, invasion and surgical curability, is closely associated with a decreased overall survival in SC/ASC and AC patients (P |
| Databáze: | OpenAIRE |
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