Ixodicidal compounds from pre-domesticated Lavandula luisieri
| Autor: | F. Valcárcel, Sonia Olmeda, Nadhem Aissani, Jesus Burillo, Luis F. Julio, Carmen E. Díaz, Azucena González-Coloma |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Hyalomma lusitanicum
Lavandula luisieri Lavandula 030231 tropical medicine Pre-domesticated Positive control 01 natural sciences Necrodane-type Essential oil law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Botany hydrolate Hydroxymethyl Thymol Traditional medicine biology 010405 organic chemistry Chemistry biology.organism_classification 0104 chemical sciences Larvicidal Hexane Lamiaceae Agronomy and Crop Science |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Repositorio de Resultados de Investigación del INIA Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA INIA: Repositorio de Resultados de Investigación del INIA |
| ISSN: | 2012-3795 |
| Popis: | Several extracts from pre-domesticated Lavandula luisieri (Rozeira) Riv-Mart. (Lamiaceae) (essential oil, EO; hexane, Hx and the organic fraction of the residual hydrolate, WRO) showed larvicidal effects against the hard tick Hyalomma lusitanicum, being WRO the most active. Their content in the necrodane-type monoterpenes (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2), 5-hydroxymethyl-2,3,4,4-tetramethylcyclopent-2-en-1-one (1) and 2-(hydroxymethyl)-3,4,4-trimethyl-5-methylenecyclopent-2-en-1-one (5) correlated with these effects. Among the isolated compounds, 3,3,4,5-tetramethyl-2H-pyran-2,6(3H)-dione (7) and (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2) were the most potent ones, with activity levels within the range of the positive control thymol. These compounds represent a new class of ixodicidal agents. This work has been supported by grants AGL2012-37957, CTQ2015-64049-C3-1-R (MINECO / FEDER) and Villamagna SA. The authors are especially grateful to his Grace the Duke of Westminster and LF Julio to a JAE-CSIC predoctoral fellowship. |
| Databáze: | OpenAIRE |
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