A new bioactive Schiff base ligands derived from propylazo-N-pyrimidin-2-yl-benzenesulfonamides Mn(II) and Cu(II) complexes: Synthesis, thermal and spectroscopic characterization biological studies and 3D modeling structures
| Autor: | Mosad A. El-ghamry, Naglaa M. Ahmed, Abdelrazak M. Tawfik, S. M. Abu-El-Wafa |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Antifungal Agents Spectrophotometry Infrared Molecular model Stereochemistry Metal ions in aqueous solution Static Electricity chemistry.chemical_element Microbial Sensitivity Tests Manganese Ligands Analytical Chemistry law.invention chemistry.chemical_compound Coordination Complexes law Polymer chemistry Electron paramagnetic resonance Instrumentation Schiff Bases Spectroscopy Sulfonamides Schiff base Bacteria Ligand Electric Conductivity Electron Spin Resonance Spectroscopy Fungi Temperature Copper Atomic and Molecular Physics and Optics Anti-Bacterial Agents Thermogravimetry chemistry Spectrophotometry Ultraviolet |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 97:1172-1180 |
| ISSN: | 1386-1425 |
| DOI: | 10.1016/j.saa.2012.07.102 |
| Popis: | New series of Schiff base ligand H(2)L and their Cu(II) and Mn(II) complexes derived from azosulfapyrimidine were synthesized and characterized by elemental and thermal studies conductance measurements IR, electronic and EPR spectra. 3D modeling of the ligand indicate that azo group does not participate in complex formation and surface potential on one of the ligand under study indicate that electron density around azomethine groups are much higher than the azo group therefore coordination takes place around azomethine groups. The variety in the geometrical structures depends on the nature of both the metal ions and the Schiff base ligands. The thermo kinetic parameters are calculated and discussed. The biological activities of the ligands and complexes have been screened in vitro against some bacteria and fungi to study their capacity to inhibit their growth and to study the toxicity of the compounds. |
| Databáze: | OpenAIRE |
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