Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect
| Autor: | Zuzana Lhotská, Milan Jirků, Lucia Frgelecová, Evan Morien, Oldřiška Kadlecová, Klára J. Petrželková, Kateřina Jirků-Pomajbíková |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) colitis medicine.drug_class microbial changes Antibiotics Microbiology Article 03 medical and health sciences 0302 clinical medicine Immune system immune markers Virology intestinal inflammation parasitic diseases medicine Helminths Colonization Hymenolepis diminuta Colitis lcsh:QH301-705.5 helminth biology Host (biology) biology.organism_classification medicine.disease 030104 developmental biology lcsh:Biology (General) bacterial microbiota Bacteria 030215 immunology |
| Zdroj: | Microorganisms Microorganisms, Vol 9, Iss 226, p 226 (2021) Volume 9 Issue 2 |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9020226 |
| Popis: | Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and the aim of this study was to determine whether disruption of the microflora during worm colonization can affect the course of intestinal inflammation. We added a phase for disrupting the intestinal microbiota using antibiotics to the experimental design for which we previously demonstrated the protective effect of H. diminuta. We monitored the immunological markers, clinical parameters, bacterial microbiota, and histological changes in the colon of rats. After a combination of colonization, antibiotics, and colitis induction, we had four differently affected experimental groups. We observed a different course of the immune response in each group, but no protective effect was found. Rats treated with colonization and antibiotics showed a strong induction of the Th2 response as well as a significant change in microbial diversity. The microbial results also revealed differences in the richness and abundance of some bacterial taxa, influenced by various factors. Our data suggest that interactions between the tapeworm and bacteria may have a major impact on its protective effect. |
| Databáze: | OpenAIRE |
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