Antihyperglycemic and Antioxidant Activity of Fructus hordei Germinatus Extract on Streptozotocin-induced Diabetic Rats
| Autor: | Zuo-jie Luo, Xing-huan Liang, Gui Qing Luo, Hua Wei, Jie Zhang, Ying-fen Qin, Biao-liang Wu |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Creatinine medicine.medical_specialty Antioxidant Insulin medicine.medical_treatment Glutathione peroxidase Pharmaceutical Science Glutathione medicine.disease Lipid peroxidation chemistry.chemical_compound Blood serum Endocrinology Fructus hordei Germinatus Diabetic Antihyperglycemic Lipid peroxidation Antioxidant Fasting blood glucose Creatinine Urea chemistry Internal medicine Diabetes mellitus medicine Pharmacology (medical) |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 14, No 9 (2015); 1651-1657 |
| ISSN: | 1596-9827 1596-5996 |
| Popis: | Purpose: To explore the antihyperglycemic and antioxidant effects of Fructus Hordei Germinatus extract (FHGE) in diabetic rats.Methods: The aqueous extract of FHG was obtained by steeping the dried Fructus Hordei Germinatus in water at 60oC three times, each for 1 h before first drying in an oven and then freeze-drying the last extract thus obtained. Antihyperglycemic effect was measured by blood glucose and plasma insulin levels. Oxidative stress was evaluated in liver and kidney by antioxidant markers, viz, lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT), while blood serum levels of creatinine and urea were also determined in both diabetic control and treated rats.Results: Compared with diabetic rats, oral administration of FHGE at a concentration of 20, 40 and 80 mg/kg daily for 45 days showed a significant decrease in fasting blood glucose (p < 0.05) and increased insulin (p < 0.05) level,. Furthermore, it significantly reduced biochemical parameters (serum creatinine and serum urea, p < 0.05)). The treatment also resulted in significant increase in GSH, GPx (p < 0.05), SOD and CAT (p < 0.05), as well as decreased LPO (p < 0.05) level in the liver and kidney of diabetic rats.Conclusion: The results suggest that FHGE may effectively normalize the impaired antioxidant status in streptozotocin-induced diabetes in a dose-dependent manner. FHGE has a protective effect against lipid peroxidation by scavenging free radicals and is thus capable of reducing the risk of diabetic complications.Keywords: Fructus hordei Germinatus, Diabetic, Antihyperglycemic, Lipid peroxidation, Antioxidant, Fasting blood glucose, Creatinine, Urea |
| Databáze: | OpenAIRE |
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