Glucosylceramide Synthase Protects Glioblastoma Cells Against Autophagic and Apoptotic Death Induced by Temozolomide and Paclitaxel
| Autor: | Laura Riboni, Paola Giussani, Manuela Caroli, F. De Zen, E. Riccitelli, L. Brioschi, R. Campanella, Sergio M. Gaini, Rosaria Bassi, V. Anelli, Paola Viani |
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| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Ceramide Paclitaxel Cell Survival medicine.medical_treatment Antineoplastic Agents Apoptosis Ceramides Central Nervous System Neoplasms chemistry.chemical_compound Cell Line Tumor Autophagy Temozolomide medicine Humans Cytotoxic T cell Cytotoxicity Antineoplastic Agents Alkylating Cell Proliferation Chemotherapy General Medicine Antineoplastic Agents Phytogenic Cell biology Dacarbazine Oncology chemistry Drug Resistance Neoplasm Glucosyltransferases Cell culture Cancer research Glioblastoma medicine.drug |
| Zdroj: | Cancer Investigation. 30:27-37 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.3109/07357907.2011.629379 |
| Popis: | Glioblastoma is a deadly cancer with intrinsic chemoresistance. Understanding this property will aid in therapy. Glucosylceramide synthase (GCS) is associated with resistance and poor outcome; little is known about glioblastomas. In glioblastoma cells, temozolomide and paclitaxel induce ceramide increase, which in turn promotes cytotoxicity. In drug-resistant cells, both drugs are unable to accumulate ceramide, increased expression and activity of GCS is present, and its inhibitors hinder resistance. Resistant cells exhibit cross-resistance, despite differing in marker expression, and cytotoxic mechanism. These findings suggest that GCS protects glioblastoma cells against autophagic and apoptotic death, and contributes to cell survival under chemotherapy. |
| Databáze: | OpenAIRE |
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