Natural moisturizing factors in children with and without eczema: Associations with lifestyle and genetic factors
| Autor: | Torben Barington, T.K. Jensen, M.N. Basu, Charlotte G. Mortz, S. Halken |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Eczema Dermatology Filaggrin Proteins Intermediate Filament Proteins Internal medicine Genotype Dry skin medicine Skin/metabolism Humans Prospective Studies Child Genotyping Life Style Skin Past medical history business.industry Infant Atopic dermatitis medicine.disease Eczema/genetics Infectious Diseases Intermediate Filament Proteins/genetics Case-Control Studies Child Preschool Cohort Mutation Birth Cohort Moisturizer medicine.symptom business Filaggrin |
| Zdroj: | Basu, M N, Mortz, C G, Jensen, T K, Barington, T & Halken, S 2022, ' Natural moisturizing factors in children with and without eczema : Associations with lifestyle and genetic factors ', Journal of The European Academy of Dermatology and Venereology, vol. 36, no. 2, pp. 255-262 . https://doi.org/10.1111/jdv.17787 |
| ISSN: | 1468-3083 |
| Popis: | Background: Filaggrin-derived natural moisturizing factors (NMF) play an important role in skin barrier function and in atopic dermatitis (AD). Its deficiency is associated with dry skin and increased surface pH. Studies on childhood environmental exposures and associations with NMF levels are scarce. Objectives: To investigate previous exposures and genetic factors and their associations with NMF levels in young children. Methods: In a case-control study nested in a prospective birth cohort (Odense Child Cohort), 169 healthy controls (HC) and 99 children with AD were included consecutively at the age of 7 years based on previous responses from questionnaires administered at 18 months, 3 years and 5 years, pertaining to past medical history, including allergy-specific questions. NMF levels were measured via a stratum corneum tape-stripping technique, genotyping for filaggrin (FLG) gene variants was performed and data on external exposures, including usage of moisturizer and topical steroids, antibiotics and early pet exposures, were obtained from questionnaires. Results: Natural moisturizing factors levels were significantly lower in AD participants compared to HC (P < 0.001). This significance persisted after stratifying for AD subgroups of present AD, current AD during the last year and previous AD (P < 0.001, P = 0.039, P = 0.009 respectively). There was a significant association between NMF and FLG genotype (P = 0.016, P = 0.002 for HC, AD respectively). NMF levels were negatively correlated with early age moisturizer use (2 cytokine milieu suppressing these levels. |
| Databáze: | OpenAIRE |
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