A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms

Autor: Bo Liu, Kosuke Ogawa, Yuko Kinowaki, Daisuke Ban, Takumi Akashi, Atsushi Kudo, Toshiro Ogura, Shinji Tanaka, Hiroaki Ono, Minoru Tanabe, Yusuke Mitsunori
Rok vydání: 2019
Předmět:
Zdroj: Journal of Gastroenterology. 54:819-828
ISSN: 1435-5922
0944-1174
DOI: 10.1007/s00535-019-01570-0
Popis: The prognostic importance of the neuroendocrine (NE) markers involving neural cell adhesion molecule (NCAM) has been unclear enough to be adopted for WHO classification in patients with pancreatic neuroendocrine neoplasms (Pan-NENs). This study aimed to elucidate whether the three NE markers such as chromogranin A, synaptophysin, and NCAM decide prognoses for patients with well-differentiated tumors. Between April 2002 and October 2018, 217 patients were included in this study. Tissue samples from tumors of Pan-NENs were immunochemically stained for the aforementioned NE markers. Diffuse and intense staining was defined as positive, while faint or focal staining and non-staining were considered negative. The median age of patients was 55 years. The median observation period was 1415 days. In multivariate analysis of progression-free survival (PFS), liver metastasis, Ki-67 index, and triple-positive staining of NE markers were risk factors. The 5-year PFS rate of patients with and without triple-positive NE markers was 56.3% and 23.8%, respectively (P
Databáze: OpenAIRE
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