Acute effect of an infusion of Montanoa tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats
| Autor: | Juan Francisco Rodríguez-Landa, Mario Caba, María de Jesús Rovirosa-Hernández, Abraham Puga-Olguín, Miguel Carro-Juárez, Margarita Virginia Saavedra-Vélez, Francisco García-Orduña, Omar Lagunes-Merino |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
0211 other engineering and technologies lcsh:Medicine Antidepressant 02 engineering and technology 01 natural sciences Open field Supraoptic nucleus Internal medicine 021105 building & construction Paraventricular nucleus medicine Fluoxetine biology business.industry Montanoa tomentosa lcsh:R Biological activity biology.organism_classification Cihuapatli 0104 chemical sciences 010404 medicinal & biomolecular chemistry Endocrinology Complementary and alternative medicine Oxytocin Natural Original Article Forced swim test business human activities hormones hormone substitutes and hormone antagonists medicine.drug Behavioural despair test |
| Zdroj: | Journal of Traditional and Complementary Medicine, Vol 10, Iss 1, Pp 45-51 (2020) Journal of Traditional and Complementary Medicine |
| ISSN: | 2225-4110 |
| Popis: | Background and aim In Mexican traditional medicine, Montanoa tomentosa (Mt) has been used as a remedy for reproductive impairments and mood swings. In pre-clinical research, both the extract and some of its active metabolites have produced oxytocinergic-like effects on female reproductive organs; however, there are no detailed studies of its effects on mood swing and brain structures. The aim of this study, was to analyze the behavioral effects of acute administration of a Mt infusion on male rats, during the Open Field (OFT) and Forced Swim (FST) Tests, and their association with the activation of oxytocin (OXT) cells, indicated by Fos protein (Fos/OXT) in the paraventricular (PVN) and supraoptic nuclei (SON). Experimental procedure 52 adult male Wistar rats were assigned to two conditions; with FST (n = 8), or without (n = 5). Each integrated condition included four groups [Control, Vehicle, Fluoxetine (Flx; 10 mg/kg), and Mt (50 mg/kg), p.o.]. Results and conclusion Mt and Flx treatment produced an anti-despair-like effect on the FST, but no significant changes in locomotor activity. Also, the Mt infusion -but not Flx-significantly increased the number of Fos/OXT cells in the PVN and SON, regardless of the condition, compared to the control and vehicle groups. These results show that Mt, but not Flx, produces an anti-despair-like effect that could be associated with the activation of OXT cells in PVN and SON. This study thus contributes to our knowledge of the pharmacological activity of Mt infusions, which could be a natural antidepressant agent with future clinical relevance. Graphical abstract Image 1 Highlights 1 An anti-despair-like effect. 2 Activation of oxytocin neurons in the Paraventricular and Supraoptic Nuclei. 3 Could be exerting a protective effect against stress in short-term. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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