Aberrant salience in first-episode psychosis: Longitudinal stability and treatment-response
| Autor: | Federica Paterlini, Andrea Raballo, Ilaria Scazza, Sara Garlassi, Simona Pupo, Lorenzo Pelizza, Luigi Rocco Chiri, Michele Poletti, Silvia Azzali |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
early psychosis
Psychosis medicine.medical_treatment Population aberrant salience Correlation first episode psychosis medicine Humans Antipsychotic education early detection Biological Psychiatry education.field_of_study Positive and Negative Syndrome Scale Salience (language) Psychopathology business.industry medicine.disease Early intervention in psychosis Psychiatry and Mental health early intervention Psychotic Disorders Pshychiatric Mental Health business Clinical psychology Antipsychotic Agents |
| Popis: | Aim Aberrant salience (AS) is considered a putative predisposing factor for the onset of psychosis. However, despite several studies conducted in the general population, research in early psychosis is still relatively scarce. The main purposes of this study were to investigate any relevant correlation of AS with functioning and psychopathology in young patients with first episode psychosis (FEP), and to analyse the longitudinal stability of AS across a 1 year follow-up period. Methods All the participants (139 FEP), aged 13-35 years, completed the Aberrant Salience Inventory (ASI), the Comprehensive Assessment of At-Risk Mental States (CAARMS), and the Positive And Negative Syndrome Scale (PANSS). Spearman correlation analysis among psychopathological parameters were performed both at baseline and after the 1 year of follow-up. Results Across the follow-up, FEP patients showed a significant decrease in the ASI total score. This reduction was specifically associated with the number of individual cognitive-behavioural therapy sessions offered to FEP individuals in the same time period (and not with antipsychotic dose at baseline). Conclusions AS is clinically significant in FEP patients. However, it tends to ameliorate over time together with the delivery of specialized, person-tailored FEP treatments within a specific "Early Intervention in Psychosis" protocol. |
| Databáze: | OpenAIRE |
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