Intestinal-level anti-inflammatory bioactivities of catechin-rich green tea: Rationale, design, and methods of a double-blind, randomized, placebo-controlled crossover trial in metabolic syndrome and healthy adults
| Autor: | Yael Vodovotz, Priyankar Dey, Guy Brock, Richard S. Bruno, Geoffrey Y. Sasaki, Zhongtang Yu, Joanna K Hodges, Jiangjiang Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
BMI
body mass index LBP LPS binding protein TLR4 Toll-like receptor-4 Inflammation Green tea extract Gut microbiota Gut flora Pharmacology SCFA short chain fatty acid Placebo Article Catechin 03 medical and health sciences Gut dysbiosis 0302 clinical medicine medicine Gut barrier function 030212 general & internal medicine lcsh:R5-920 Intestinal permeability biology Tea TNF- α tumor necrosis factor-α business.industry General Medicine medicine.disease biology.organism_classification Crossover study Metabolic syndrome Endotoxemia Clinical trial NFκB nuclear factor κB GTE green tea extract PCoA principal coordinates analysis LPS lipopolysaccharides MetS metabolic syndrome medicine.symptom business lcsh:Medicine (General) 030217 neurology & neurosurgery |
| Zdroj: | Contemporary Clinical Trials Communications Contemporary Clinical Trials Communications, Vol 17, Iss, Pp-(2020) |
| ISSN: | 2451-8654 |
| Popis: | Metabolic endotoxemia initiates low-grade chronic inflammation in metabolic syndrome (MetS) and provokes the progression towards more advanced cardiometabolic disorders. Our recent works in obese rodent models demonstrate that catechin-rich green tea extract (GTE) improves gut barrier integrity to alleviate the translocation of gut-derived endotoxin and its consequent pro-inflammatory responses mediated through Toll-like receptor-4/nuclear factor κB (TLR4/NFκB) signaling. The objective of this clinical trial is to establish the efficacy of GTE to alleviate metabolic endotoxemia-associated inflammation in persons with MetS by improving gut barrier function. We plan a double-blind, placebo-controlled cross-over trial in persons with MetS and age- and gender-matched healthy persons (18–65 y; n = 20/group) who will receive a low-energy GTE-rich (1 g/day; 890 mg total catechins) confection snack food while following a low-polyphenol diet for 28 days. Assessments will include measures of circulating endotoxin (primary outcome) and secondary outcomes including biomarkers of endotoxin exposure, region-specific measures of intestinal permeability, gut microbiota composition, diversity, and functions, intestinal and systemic inflammatory responses, and catechins and microbiota-derived catechin metabolites. Study outcomes will provide the first report of the GTE-mediated benefits that alleviate gut barrier dysfunction in relation to endotoxemia-associated inflammation in MetS persons. This is expected to help establish an effective dietary strategy to mitigate the growing burden of MetS that currently affects ~35% of Americans. Keywords: Catechin, Endotoxemia, Gut barrier function, Gut dysbiosis, Gut microbiota, Inflammation, Metabolic syndrome, Tea |
| Databáze: | OpenAIRE |
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