Inhibition of Cutaneous UV Light-induced Tumor Necrosis Factor-α Protein Production by Allotrap 1258, a Novel Immunomodulatory Peptide¶

Autor:	Traci A. Wilgus, Tatiana M. Oberyszyn, Michelle L. Parrett, Mary S. Ross, Fredika M. Robertson, Jacky Woo, Roland Buelow, Kathleen L. Tober, Suhasini Iyer
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Epidermis (botany) Inflammation Peptide General Medicine Pharmacology Biology Biochemistry In vitro Hairless Immune system chemistry In vivo Immunology medicine Tumor necrosis factor alpha medicine.symptom Physical and Theoretical Chemistry
Zdroj:	Photochemistry and Photobiology. 73:184-190
ISSN:	0031-8655
DOI:	10.1562/0031-8655(2001)0730184ioculi2.0.co2
Popis:	Peptides derived from the heavy chain of the HLA Class-I molecules have been shown to modulate immune responses both in vivo and in vitro. Using a computer-aided rational drug design approach, novel immunomodulatory peptides were designed based on peptide 2702.75–85, derived from HLA-B2702. Several peptides were identified which had increased immunomodulatory activity, including peptides RDP1258 and its d-isomer the peptide Allotrap 1258. The present study using Skh/hr hairless mouse skin model evaluated the in vivo effects of Allotrap 1258 on acute UVB-induced skin inflammation. Here we demonstrate that intraperitoneal administration of Allotrap 1258 1 h prior to UV exposure resulted in significantly diminished levels of UV-induced tumor necrosis factor (TNF)-α protein production in the epidermis but had no effect on other parameters of the acute UV-induced inflammatory response. By virtue of its ability to suppress TNF-α protein production, Allotrap 1258 could prove to be an effective modulator...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7de46909497118975065541dec4d28 https://doi.org/10.1562/0031-8655(2001)0730184ioculi2.0.co2 Zobrazit plný text záznamu Plný text