Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus

Autor:	Jing Shaw, David R. Kilpatrick, Linda Venczel, Elizabeth Blackman, Hiroyuki Shimizu, Mauricio Landaverde, Fernando Laender, Ciro de Quadros, Zacarı́as Garib, M. Steven Oberste, Gina Tambini, Olen M. Kew, Victoria Morris-Glasgow, Tetsuo Yoneyama, Stephen L. Cochi, Cristina Pedreira, Cara C. Burns, Harrie van der Avoort, Jean André, Tatsuo Miyamura, Mark A. Pallansch, C. Jason Freeman, Roland W. Sutter, Jaume Jorba
Rok vydání:	2002
Předmět:	Male Adolescent Genes Viral Molecular Sequence Data ved/biology.organism_classification_rank.species Enterovirus C medicine.disease_cause Virus Disease Outbreaks Mice Capsid Animals Humans Point Mutation Medicine Child Recombination Genetic Multidisciplinary Virulence Immunization Programs business.industry ved/biology Poliovirus Dominican Republic Vaccination Infant Outbreak medicine.disease Virology Haiti Poliomyelitis Child Preschool Poliovirus Vaccine Oral Population Surveillance Enterovirus Capsid Proteins Female Viral disease 5' Untranslated Regions business
Zdroj:	Science. 296:356-359
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1068284
Popis:	An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000–2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998–1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7d3822d035316c65432976f78adcf9 https://doi.org/10.1126/science.1068284 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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