Evaluation of the causes of sex disparity in heart failure trials
| Autor: | Holly Morgan, Aish Sinha, Margaret Mcentegart, Suzanna Marie Hardman, Divaka Perera |
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| Rok vydání: | 2022 |
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| Zdroj: | Morgan, H, Sinha, A, McEntegart, M, Hardman, S M & Perera, D 2022, ' Evaluation of the causes of sex disparity in heart failure trials ', Heart, vol. 108, no. 19, 320696, pp. 1547-1552 . https://doi.org/10.1136/heartjnl-2021-320696 |
| ISSN: | 1468-201X 1355-6037 |
| Popis: | ObjectivesCardiovascular disease is one of the leading causes of mortality and morbidity in women. Despite this, even in contemporary research, female patients are poorly represented in trials. This study aimed to explore reasons behind the sex disparity in heart failure (HF) trials.MethodsHF trials published in seven high-impact clinical journals (impact factor >20), between 2000 and 2020, were identified. Trials with over 300 participants of both sexes were included. Large HF registries, as well as population statistics, were also identified using the same criteria.ResultsWe identified 146 HF trials, which included 248 620 patients in total. The median proportion of female patients was 25.8%, with the lowest proportions seen in trials enrolling patients with ischaemic cardiomyopathy (17.9%), severe systolic dysfunction (left ventricular ejection fraction (LVEF) ConclusionsA significant sex disparity was identified in HF trials, most visible in trials assessing patients with severely reduced LVEF and ischaemic aetiology. This is likely due to a complex interplay between enrolment bias and biological variation. Furthermore, the degree of both these aspects may vary according to trial type. Going forward, we should encourage all HF trials to appraise their recruitment log and suggest reasons for any reported sex disparity. |
| Databáze: | OpenAIRE |
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