Gut Microbiota Changes in Patients with Bipolar Depression
| Autor: | M. Elizabeth Sublette, Haifeng Lu, Zhiying Hu, Ang Li, Manli Huang, Jianbo Hu, Jing Lu, Ming D. Li, Lie-min Ruan, Yi Xu, Tingting Huang, Yanli Du, Hua Zhang, Dandan Wang, Tingting Mou, Weihua Zhou, Chee H. Ng, Qiaoqiao Lu, Ning Wei, Jianbo Lai, Shaojia Lu, Jinfeng Duan, Jingjing Li, Shaohua Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Firmicutes
General Chemical Engineering General Physics and Astronomy Medicine (miscellaneous) 02 engineering and technology Gut flora 010402 general chemistry 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) digestive system medicine General Materials Science Bipolar disorder lcsh:Science bipolar disorder biology Full Paper gut microbiota Chemistry General Engineering Area under the curve biomarkers Full Papers quetiapine 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification 0104 chemical sciences Immunology Biomarker (medicine) Quetiapine 16S rRNA gene sequence lcsh:Q sense organs Metabolic syndrome 0210 nano-technology Dysbiosis medicine.drug |
| Zdroj: | Advanced Science Advanced Science, Vol 6, Iss 14, Pp n/a-n/a (2019) |
| ISSN: | 2198-3844 |
| Popis: | This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared with healthy controls (HCs), to examine the effects of quetiapine treatment on the microbiota, and to explore the potential of microbiota as a biomarker for BD diagnosis and treatment outcome. Analysis of 16S‐ribosomal RNA gene sequences reveals that gut microbial composition and diversity are significantly different between BD patients and HCs. Phylum Bacteroidetes and Firmicutes are the predominant bacterial communities in BD patients and HCs, respectively. Lower levels of butyrate‐producing bacteria are observed in untreated patients. Microbial composition changes following quetiapine treatment in BD patients. Notably, 30 microbial markers are identified on a random forest model and achieve an area under the curve (AUC) of 0.81 between untreated patients and HCs. Ten microbial markers are identified with the AUC of 0.93 between responder and nonresponder patients. This study characterizes the gut microbiota in BD and is the first to evaluate microbial changes following quetiapine monotherapy. Gut microbiota‐based biomarkers may be helpful in BD diagnosis and predicting treatment outcome, which need further validations. |
| Databáze: | OpenAIRE |
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