Intrathecal IgG synthesis and autoantibody-secreting cells in multiple sclerosis
| Autor: | Finn Sellebjerg, Claus V. Jensen, Michael Christiansen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Proteolipid protein 1 Immunology Intrathecal Immunoglobulin G Leukocyte Count Cerebrospinal fluid Antibody Specificity medicine Humans Immunology and Allergy Myelin Proteolipid Protein Autoantibodies B-Lymphocytes biology medicine.diagnostic_test business.industry Multiple sclerosis Autoantibody Myelin Basic Protein Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Myelin basic protein Neurology biology.protein Female Neurology (clinical) business |
| Zdroj: | Journal of Neuroimmunology. 108:207-215 |
| ISSN: | 0165-5728 |
| Popis: | We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect