Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition
| Autor: | Andrea D. Spadoni, Monte S. Buchsbaum, Daniel M. Stout, Victoria B. Risbrough, Scott C. Matthews, Irina A. Strigo, Alan N. Simmons |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology Biochemistry lcsh:RC346-429 0302 clinical medicine Endocrinology TBI screening and diagnosis medicine.diagnostic_test Depression lcsh:QP351-495 Cognition PTSD Anticipation Articles from the Special Issue on Imaging Stress Edited by Michael R Bruchas and Alan Simmons Detection medicine.anatomical_structure Mental Health Neurological Biomedical Imaging Psychology Physical Injury - Accidents and Adverse Effects Grey matter Trauma Basic Behavioral and Social Science lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Neuroimaging Canonical correlation Clinical Research Multimodal imaging Behavioral and Social Science medicine Biological neural network Middle frontal gyrus Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:Neurology. Diseases of the nervous system Traumatic Head and Spine Injury Endocrine and Autonomic Systems Neurosciences Brain Disorders 4.1 Discovery and preclinical testing of markers and technologies 030104 developmental biology lcsh:Neurophysiology and neuropsychology Verbal memory Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Stress Neurobiology of Stress, Vol 9, Iss, Pp 241-250 (2018) |
| ISSN: | 2352-2895 |
| Popis: | Trauma-related disorders of affect and cognition (TRACs) are associated with a high degree of diagnostic comorbidity, which may suggest that these disorders share a set of underlying neural mechanisms. TRACs are characterized by aberrations in functional and structural circuits subserving verbal memory and affective anticipation. Yet, it remains unknown how the neural circuitry underlying these multiple mechanisms contribute to TRACs. Here, in a sample of 47 combat Veterans, we measured affective anticipation using functional magnetic resonance imaging (fMRI), verbal memory with fluorodeoxyglucose positron emission tomography (FDG-PET), and grey matter volume with structural magnetic resonance imaging (sMRI). Using a voxel-based multimodal canonical correlation analysis (mCCA), the set of neural measures were statistically integrated, or fused, with a set of TRAC symptom measures including mild traumatic brain injury (mTBI), posttraumatic stress, and depression severity. The first canonical correlation pair revealed neural convergence in clusters encompassing the middle frontal gyrus and supplemental motor area, regions implicated in top-down cognitive control and affect regulation. These results highlight the potential of leveraging multivariate neuroimaging analysis for linking neurobiological mechanisms associated with TRACs, paving the way for transdiagnostic biomarkers and targets for treatment. Keywords: Trauma, TBI, PTSD, Multimodal imaging, Canonical correlation |
| Databáze: | OpenAIRE |
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