Inverse relationship between human erythrocyte fructose-6-phosphate and short-chain fatty acid levels
| Autor: | Michele C. Kingston, Jean A. Monro, Basant K. Puri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Chromatography Gas Erythrocytes Dietary Sugars Fructose 6-phosphate Butyrate Fructose Carbohydrate metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Spectroscopy Fourier Transform Infrared medicine Humans chemistry.chemical_classification Short-chain fatty acid Fructosephosphates Gluconeogenesis General Medicine Middle Aged Fatty Acids Volatile 030104 developmental biology Endocrinology Glucose chemistry Liver Fermentation Propionate Female Pyruvic acid Propionates 030217 neurology & neurosurgery |
| Zdroj: | Medical hypotheses. 121 |
| ISSN: | 1532-2777 |
| Popis: | In muscle cells, fructose is initially metabolised to fructose-6-phosphate. In the liver, fructose is metabolised to fructose-1-phosphate and thence to glyceraldehydes, which in turn can either enter glycogenolysis via pyruvate or gluconeogenesis via fructose-1,6-bisphosphate and fructose-6-phosphate. High levels of fructose-1-phosphate inhibit both glycogenolysis and gluconeogenesis. We hypothesised that, if systemically absorbed short-chain fatty acids constitute a major metabolic fate of unabsorbed dietary fructose, then levels of erythrocyte fructose-6-phosphate would be inversely correlated with plasma levels of short-chain fatty acids. The aim of this study was to test this hypothesis in respect of the three main short-chain fatty acids acetate, propionate and butyrate. Venous blood samples from 39 patients (16 male, 23 female, mean (standard error) age 42.4 (3.3) years) were analysed. Erythrocyte fructose-6-phosphate was measured using quantitative Fourier transform infrared spectrometry following gel electrophoresis, while plasma acetate, propionate and butyrate levels were measured using gas-liquid chromatography. The erythrocyte fructose-6-phosphate level was inversely correlated with the plasma acetate (r = −0.30, p = 0.06), propionate (r = −0.31, p = 0.05) and butyrate (r = −0.40, p = 0.01). These results support our hypothesis. The conversion of unabsorbed dietary fructose into short-chain fatty acids may represent a protective mechanism against the adverse effects of hypoglycaemia. |
| Databáze: | OpenAIRE |
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