Plasma Metabolome Alterations Associated with Extrauterine Growth Restriction
| Autor: | Montserrat Izquierdo Renau, Carles Lerin, Coral Barbas, Isabel Iglesias Platas, Carla Balcells Esponera, Marta Ramon-Krauel, Danuta Dudzik, Beatriz Del Rey Hurtado de Mendoza |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Multivariate analysis Physiology lcsh:TX341-641 Gestational Age growth failure Glycerophospholipids Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Metabolomics Growth restriction 030225 pediatrics Metabolome Hospital discharge Humans Infant Very Low Birth Weight Medicine Prospective Studies preterm infants Infant Nutritional Physiological Phenomena Sphingolipids metabolic fingerprinting Nutrition and Dietetics business.industry Infant Newborn Gestational age Sphingolipid Failure to Thrive multiplatform untargeted metabolomics 030104 developmental biology Gestation Female business lcsh:Nutrition. Foods and food supply Biomarkers Infant Premature Food Science |
| Zdroj: | Nutrients Volume 12 Issue 4 Nutrients, Vol 12, Iss 1188, p 1188 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12041188 |
| Popis: | Very preterm infants (VPI, born at or before 32 weeks of gestation) are at risk of adverse health outcomes, from which they might be partially protected with appropriate postnatal nutrition and growth. Metabolic processes or biochemical markers associated to extrauterine growth restriction (EUGR) have not been identified. We applied untargeted metabolomics to plasma samples of VPI with adequate weight for gestational age at birth and with different growth trajectories (29 well-grown, 22 EUGR) at the time of hospital discharge. A multivariate analysis showed significantly higher levels of amino-acids in well-grown patients. Other metabolites were also identified as statistically significant in the comparison between groups. Relevant differences (with corrections for multiple comparison) were found in levels of glycerophospholipids, sphingolipids and other lipids. Levels of many of the biochemical species decreased progressively as the level of growth restriction increased in severity. In conclusion, an untargeted metabolomic approach uncovered previously unknown differences in the levels of a range of plasma metabolites between well grown and EUGR infants at the time of discharge. Our findings open speculation about pathways involved in growth failure in preterm infants and the long-term relevance of this metabolic differences, as well as helping in the definition of potential biomarkers. |
| Databáze: | OpenAIRE |
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