Disseminated Bacillus Calmette-Guérin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II
| Autor: | Kenneth R. Cooke, J. Arnold, Blanca E. Gonzalez, Jeffery J. Auletta, Michael R. Jacobs, Rachel A. Egler, Rolla Abu-Arja, Linda Cabral |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_treatment
Hematopoietic stem cell transplantation Article Immune system medicine Humans Lymph node Ethambutol Mycobacterium Infections Transplantation Mycobacterium bovis Severe combined immunodeficiency biology business.industry Hematopoietic Stem Cell Transplantation Bare lymphocyte syndrome Infant medicine.disease biology.organism_classification Infectious Diseases medicine.anatomical_structure Immunology BCG Vaccine Female Severe Combined Immunodeficiency business BCG vaccine medicine.drug |
| Zdroj: | Transplant Infectious Disease. 16:830-837 |
| ISSN: | 1398-2273 |
| DOI: | 10.1111/tid.12263 |
| Popis: | We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Guérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy. |
| Databáze: | OpenAIRE |
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