Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department
| Autor: | Cenker Eken, Mustafa Serinken, Yalcin Golcuk, Kamil Tunay |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Ketoprofen ketoprofen Adolescent Visual analogue scale Administration Topical Placebo law.invention ankle sprain 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Humans Outpatient clinic Medicine Ankle Injuries 030212 general & internal medicine topical Child Adverse effect Pain Measurement business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Emergency department Confidence interval Anesthesia Pediatrics Perinatology and Child Health Sprains and Strains Emergency Medicine Female 030211 gastroenterology & hepatology Emergency Service Hospital business medicine.drug |
| Zdroj: | Pediatric Emergency Care. |
| ISSN: | 0749-5161 |
| Popis: | Objective Despite the favorable data concerning topical agents use in outpatient clinics, they are not commonly in emergency departments (EDs). The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in children presenting with ankle sprain to the ED. Study Design Children between 7 and 18 years old presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered in a 5-cm area locally. Pain improvements at 15 and 30 minutes were measured by visual analog scale. Results Median pain reductions at 15 minutes for ketoprofen and placebo groups were 27.5 (16-39) and 5 (4-10), respectively. Median changes in pain intensity at 30 minutes for ketoprofen and placebo gel groups were 48 (43-52) and 9 (6-16), respectively. When compared 2 arms for the pain improvement at 15 and 30 minutes, the differences between 2 study drugs were 20 (13-28) and 35 (29-41), respectively. There were 7 (12.7%) rescue drug needs in the placebo group and 1 (1.7%) in the ketoprofen group (difference, 10.9%; 95% confidence interval, -6% to 7%; P = 0.83). There were no adverse effects in either group. Conclusions Ketoprofen gel is superior to placebo in ceasing pain in children presenting with ankle sprain to the ED with a high safety profile. © Wolters Kluwer Health, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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