Repeated High Rate Facet Capsular Stretch at Strains That are Below the Pain Threshold Induces Pain and Spinal Inflammation With Decreased Ligament Strength in the Rat
| Autor: | Ben A. Bulka, Sonia Kartha, Harrison R. Troche, Nicholas S. Stiansen, Beth A. Winkelstein |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Pain Threshold Facet (geometry) Biomedical Engineering medicine.disease_cause Facet joint Weight-bearing Weight-Bearing 03 medical and health sciences 0302 clinical medicine Physiology (medical) Threshold of pain medicine Animals Inflammation 030222 orthopedics Articular capsule of the knee joint Ligaments business.industry Biomechanics Spinal cord musculoskeletal system Research Papers Biomechanical Phenomena Rats medicine.anatomical_structure Spinal Cord Anesthesia Ligament Stress Mechanical business 030217 neurology & neurosurgery |
| Zdroj: | Journal of biomechanical engineering. 140(8) |
| ISSN: | 1528-8951 |
| Popis: | Repeated loading of ligamentous tissues during repetitive occupational and physical tasks even within physiological ranges of motion has been implicated in the development of pain and joint instability. The pathophysiological mechanisms of pain after repetitive joint loading are not understood. Within the cervical spine, excessive stretch of the facet joint and its capsular ligament has been implicated in the development of pain. Although a single facet joint distraction (FJD) at magnitudes simulating physiologic strains is insufficient to induce pain, it is unknown whether repeated stretching of the facet joint and ligament may produce pain. This study evaluated if repeated loading of the facet at physiologic nonpainful strains alters the capsular ligament's mechanical response and induces pain. Male rats underwent either two subthreshold facet joint distractions (STFJDs) or sham surgeries each separated by 2 days. Pain was measured before the procedure and for 7 days; capsular mechanics were measured during each distraction and under tension at tissue failure. Spinal glial activation was also assessed to probe potential pathophysiologic mechanisms responsible for pain. Capsular displacement significantly increased (p = 0.019) and capsular stiffness decreased (p = 0.008) during the second distraction compared to the first. Pain was also induced after the second distraction and was sustained at day 7 (p |
| Databáze: | OpenAIRE |
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