Quantitative considerations about the size dependence of cellular entry and excretion of colloidal nanoparticles for different cell types
| Autor: | Yanan Kang, Leroy Marwin Nack, Yang Liu, Bing Qi, Yalan Huang, Ziyao Liu, Indranath Chakraborty, Florian Schulz, Abdullah A. A. Ahmed, Mirco Clavo Poveda, Fereshta Hafizi, Sathi Roy, Marina Mutas, Malte Holzapfel, Carlos Sanchez-Cano, K. David Wegner, Neus Feliu, Wolfgang J. Parak |
|---|---|
| Přispěvatelé: | Publica |
| Rok vydání: | 2022 |
| Předmět: |
inorganic chemicals
Quantum dots Nanoparticle degradation technology industry and agriculture General Chemistry respiratory system Biochemistry Exocytosis Fluorescence mental disorders Uptake studies Gold nanoparticles Cell proliferation health care economics and organizations Luminescent nanoparticles |
| Zdroj: | ChemTexts. 8 |
| ISSN: | 2199-3793 |
| Popis: | Most studies about the interaction of nanoparticles (NPs) with cells have focused on how the physicochemical properties of NPs will influence their uptake by cells. However, much less is known about their potential excretion from cells. However, to control and manipulate the number of NPs in a cell, both cellular uptake and excretion must be studied quantitatively. Monitoring the intracellular and extracellular amount of NPs over time (after residual noninternalized NPs have been removed) enables one to disentangle the influences of cell proliferation and exocytosis, the major pathways for the reduction of NPs per cell. Proliferation depends on the type of cells, while exocytosis depends in addition on properties of the NPs, such as their size. Examples are given herein on the role of these two different processes for different cells and NPs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink