Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy

Autor: Vladimir Krasnik, Radka Opatrilova, Sandeep Saxena, Shivani Sinha, Shashi Kumar Bhasker, Senthamizh Prasad, Abbas Ali Mahdi, Martin Caprnda, Peter Kruzliak, Siddharth Kumar Das
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Myeloperoxidase antibody
Endocrinology
Diabetes and Metabolism
Visual Acuity
India
Retina
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
Endocrinology
Imaging
Three-Dimensional
Isoantibodies
Ophthalmology
Diabetes mellitus
Internal Medicine
medicine
Humans
Peroxidase
Diabetic Retinopathy
biology
business.industry
Significant difference
Retinal Degeneration
Models
Immunological
Reproducibility of Results
Diabetic retinopathy
Middle Aged
medicine.disease
Surgery
030104 developmental biology
Cross-Sectional Studies
Diabetes Mellitus
Type 2
Retinal Photoreceptors
Decreased Visual Acuity
030221 ophthalmology & optometry
biology.protein
Regression Analysis
Female
Antibody
business
Tomography
Optical Coherence
Retinopathy
Photoreceptor Cells
Vertebrate
Zdroj: Journal of diabetes and its complications. 31(5)
ISSN: 1873-460X
Popis: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy.Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ. The serum levels of anti-MPO antibody was analyzed using standard protocol. Association between the variables was evaluated using multiple regression analysis.A significant difference was found between the serum levels of anti-MPO antibody in various study groups (p0.001). A positive association was found between EZ disruption and levels of anti-MPO antibody [adjusted odd's ratio (AOR)=1.079, CI 1.010-1.124, p=0.04]. A significant positive correlation was found between logMAR visual acuity and grade of disruption (AOR=1.008, CI 1.006-5.688, p=0.04).An increased serum anti-MPO antibody levels is associated with retinal photoreceptor EZ disruption and decreased visual acuity in diabetic retinopathy.
Databáze: OpenAIRE
Externí odkaz: