Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)
| Autor: | L. J. Smith, Guanqing Wu, K. G. Cornish, C. P. Mountjoy, H. D. Kay |
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| Rok vydání: | 1994 |
| Předmět: |
DNA
Complementary Molecular Sequence Data Sequence alignment Biology Polymerase Chain Reaction Homology (biology) Complementary DNA Consensus Sequence Genetics Consensus sequence Animals Humans Amino Acid Sequence Gene Peptide sequence DNA Primers Base Sequence Sequence Homology Amino Acid Nucleic acid sequence Hominidae Exons General Medicine Genes p53 Macaca mulatta Virology Molecular biology African Green Monkey Tumor Suppressor Protein p53 |
| Zdroj: | Gene. 138:223-226 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/0378-1119(94)90812-5 |
| Popis: | A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa. |
| Databáze: | OpenAIRE |
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