Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats
| Autor: | João Lauro Viana de Camargo, Maria Aparecida Marchesan Rodrigues, Marina Okuyama Kishima, Dirceu Estevão, Luis Fernando Barbisan |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.disease_cause Muscle hypertrophy chemistry.chemical_compound Liver Neoplasms Experimental Internal medicine medicine Hexachlorobenzene Bioassay Animals Rats Wistar Cocarcinogenesis Chemistry Low dose Body Weight Glutathione Organ Size Medium term bioassay Fungicides Industrial Rats Endocrinology Oncology Liver Rat liver Carcinogenesis Energy Intake |
| Zdroj: | Cancer letters. 152(1) |
| ISSN: | 0304-3835 |
| Popis: | The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S -transferase placental form (GST-P + ) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P + foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide. |
| Databáze: | OpenAIRE |
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