Plasma mannose level, a putative indicator of glycogenolysis, and glucose tolerance in Japanese individuals
| Autor: | Yoshio Terada, Kumiko Yoshimura, Mari Inoue, Seiki Hirano, Yuichi Nishi, Eri Amano, Shuhei Yamada, Hikari Hayashi, Ichitomo Miwa, Yoshiharu Fukuda, Tadao Taguchi, Shogo Funakoshi, Shimpei Fujimoto, Hiroshi Takata, Satoko Ohmi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Glycogenolysis Endocrinology Diabetes and Metabolism Mannose 030209 endocrinology & metabolism Carbohydrate metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glycolipid Diabetes mellitus Internal medicine Glucose Intolerance Internal Medicine medicine Humans Monosaccharide Aged Normal glucose tolerance chemistry.chemical_classification business.industry Glucose tolerance Articles General Medicine Glucose Tolerance Test Middle Aged medicine.disease Clinical Science and Care 030104 developmental biology Endocrinology chemistry Regression Analysis Original Article Female business Glycoprotein |
| Zdroj: | Journal of Diabetes Investigation |
| ISSN: | 2040-1116 |
| Popis: | Aims/Introduction Mannose is a monosaccharide constituent of glycoproteins and glycolipids. Experiments in rats have shown previously that the plasma mannose level decreases after glucose load, but does not decrease in diabetic rats, and that hepatic glycogenolysis is a source of this plasma mannose; however, these results are not fully elucidated in humans. Plasma mannose levels before/after glucose loading in humans with various degrees of glucose intolerance were examined to analyze their association with clinical factors. Materials and Methods The 75-g oral glucose tolerance test was carried out in Japanese individuals not taking diabetes medications. Participants were classified into normal glucose tolerance, impaired glucose metabolism and diabetes mellitus groups. Insulinogenic index as an index of insulin secretion, and Matsuda Index as an index of insulin sensitivity were calculated. Mannose was assayed by the established method using high-performance liquid chromatography after labeling. Results After glucose load, the plasma mannose level decreased gradually in the normal glucose tolerance group, but did not decrease in the diabetes mellitus group. Plasma mannose changes during 120 min from baseline (M120-M0) were significantly different among the three groups (normal glucose tolerance: −16.7 ± 1.7; impaired glucose metabolism: −9.0 ± 1.9; diabetes mellitus: −1.4 ± 1.8 μmol/L [n = 25 in each group], P |
| Databáze: | OpenAIRE |
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