Promising antiparasitic agents from marine sponges
| Autor: | Mahmoud Moustafa, Osama M. S. Mostafa, Mohammed Alshehri |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Marine sponges
biology Traditional medicine QH301-705.5 Antiparasitic medicine.drug_class Leishmania donovani Plasmodium falciparum Trypanosoma brucei rhodesiense Review Novel antiparasitic drugs biology.organism_classification Antiparasitic agent Bioactive compounds Terpenoid Potent activity parasitic diseases medicine Schistosoma mansoni Biology (General) General Agricultural and Biological Sciences Haemonchus contortus |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 29, Iss 1, Pp 217-227 (2022) Saudi Journal of Biological Sciences |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2021.08.068 |
| Popis: | Parasitic diseases especially those prevail in tropical and subtropical regions severely threaten the lives of people due to available drugs found to be ineffective as several resistant strains have been emerged. Due to the complexity of the marine environment, researchers considered it as a new field to search for compounds with therapeutic efficacy, marine sponges represents the milestone in the discovery of unique compounds of potent activities against parasitic infections. In the present article, literatures published from 2010 until March 2021 were screened to review antiparasitic potency of bioactive compounds extracted from marine sponges. 45 different genera of sponges have been studied for their antiparasitic activities. The antiparasitic activity of the crude extract or the compounds that have been isolated from marine sponges were assayed in vitro against Plasmodium falciparum, P. berghei, Trypanosoma brucei rhodesiense, T. b. brucei, T. cruzi, Leishmania donovani, L. tropica, L. infantum, L. amazonesis, L. major, L. panamesis, Haemonchus contortus and Schistosoma mansoni. The majority of antiparastic compounds extracted from marine sponges were related to alkaloids and peroxides represent the second important group of antiparasitic compounds extracted from sponges followed by terpenoids. Some substances have been extracted and used as antiparasitic agents to a lesser extent like steroids, amino acids, lipids, polysaccharides and isonitriles. The activities of these isolated compounds against parasites were screened using in vitro techniques. Compounds' potent activity in screened papers was classified in three categories according to IC50: low active or inactive, moderately active and good potent active. |
| Databáze: | OpenAIRE |
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