Protective effect of grape seed and skin extract on high dosage garlic-induced renal oxidative stress
| Autor: | Oumayma Samti, Mohamed Amri, Meherzia Mokni, Alice Carrier, Sonia Hamlaoui, Ezzedine Aouani, Nadia Limam, Lamjed Marzouki, Ferid Limam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
Grape seed and skin extract H2O2 medicine.medical_treatment Lipid peroxidation Ionizable calcium Pharmacology medicine.disease_cause Kidney Superoxide dismutase chemistry.chemical_compound medicine Urea Garlic Free iron biology lcsh:RM1-950 food and beverages Malondialdehyde Protein carbonylation medicine.anatomical_structure lcsh:Therapeutics. Pharmacology Biochemistry chemistry Catalase Oxidative stress Creatinine Toxicity biology.protein Grape seed |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 7, Iss 2 (2012) Bangladesh Journal of Pharmacology, Vol 7, Iss 2, Pp 77-86 (2012) |
| ISSN: | 1991-0088 |
| Popis: | In this study, the protective role of grape seed and skin extract (GSSE) against high garlic dose-induced renal toxicity has been evaluated. Rats were intraperitoneally injected with garlic (5 g/kg bw) or GSSE (500 mg/kg bw) or a combination of garlic and GSSE at the same doses daily for one month. Renal oxidative stress markers and antioxidant status were evaluated. We also measured plasma creatinine and urea. Data showed that high garlic dose induced renal toxicity by increasing creatinine and urea and a pro-oxidative status characterized by increased malondialdehyde, carbonyl protein, calcium and H 2 O 2 , but decreased free iron. Unexpectedly garlic increased catalase but decreased peroxidase and superoxide dismutase activities. GSSE co-treatment counteracted almost all garlic-induced deleterious effects. In conclusion, high garlic dose induced a pro-oxidative state characterized by the Fenton reaction between H 2 O 2 and free iron, inducing Ca 2+ depletion, while GSSE exerted antioxidant properties and Ca 2+ repletion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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