Autor: |
Christophe Vandekerckhove, Denis Larsimont, Philip Poortmans, Christos Sotiriou, Dirk Van Gestel, Ligia Craciun, Marianne Paesmans, Alex De Caluwé, Laurence Buisseret, Michail Ignatiadis, Fabien Reyal, Martine Piccart, Drisis Stylianos, Roberto Salgado, Veys Isabelle, Emanuela Romano, Daniel Eiger |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
|
Zdroj: |
BMC cancer, 21 (1 BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021) BMC cancer BMC Cancer |
ISSN: |
1471-2407 |
Popis: |
Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, however, is lower for luminal B BC in comparison to the triple negative (TNBC) and HER2+ subtypes. The addition of immune checkpoint blockade (ICB) to NACT has the potential to increase pCR rate but is hampered by the lower immunogenicity of luminal B BC. Novel strategies are needed to stimulate the immune response and increase the response rate to ICB in luminal B BC. info:eu-repo/semantics/published |
Databáze: |
OpenAIRE |
Externí odkaz: |
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