Neo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial

Autor:	Christophe Vandekerckhove, Denis Larsimont, Philip Poortmans, Christos Sotiriou, Dirk Van Gestel, Ligia Craciun, Marianne Paesmans, Alex De Caluwé, Laurence Buisseret, Michail Ignatiadis, Fabien Reyal, Martine Piccart, Drisis Stylianos, Roberto Salgado, Veys Isabelle, Emanuela Romano, Daniel Eiger
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Oncology Cancer Research medicine.medical_specialty Early luminal B breast cancer Adenosine Durvalumab medicine.medical_treatment Breast Neoplasms Anti-PD-L1 Study Protocol Anti-CD73 Breast cancer Clinical Protocols MammaPrint Surgical oncology Internal medicine Genetics medicine Clinical endpoint Humans RC254-282 Neoplasm Staging Chemotherapy medicine.diagnostic_test business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Médecine pathologie humaine Neo-adjuvant chemotherapy Chemoradiotherapy Sciences bio-médicales et agricoles medicine.disease Combined Modality Therapy Immune checkpoint Radiation therapy Cancérologie Research Design Priming Stereotactic body radiation therapy Female Human medicine business Metabolic Networks and Pathways
Zdroj:	BMC cancer, 21 (1 BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021) BMC cancer BMC Cancer
ISSN:	1471-2407
Popis:	Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, however, is lower for luminal B BC in comparison to the triple negative (TNBC) and HER2+ subtypes. The addition of immune checkpoint blockade (ICB) to NACT has the potential to increase pCR rate but is hampered by the lower immunogenicity of luminal B BC. Novel strategies are needed to stimulate the immune response and increase the response rate to ICB in luminal B BC. info:eu-repo/semantics/published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5e0a462b9980148e1ddb357a2d8ccc http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/329892 Zobrazit plný text záznamu Full text from SpringerLink