Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds—A Review
| Autor: | Etel Faradjeva, Antony V. Samrot, Chua Yeok Mun, Lee Si Jie, S. Suresh Kumar, Ng Xiao Qi, Emmanuel Norbert Michael, Akasha Arif, Tan Chuan Sean, Amira Abubakar Mohamed, Pooi Ling Mok, Chin Hooi Sze |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
bioactive compounds business.industry Biofilm inhibition Biofilm Virulence quorum sensing biological control Review antibiofilm agents General Medicine biochemical phenomena metabolism and nutrition Antimicrobial Anti-Bacterial Agents Microbiology Biofouling biofilm-related Infections Quorum sensing R5-920 biofouling Medicine biofilms business |
| Zdroj: | Medicina, Vol 57, Iss 839, p 839 (2021) Medicina |
| ISSN: | 1648-9144 |
| Popis: | Biofilms comprising aggregates of microorganisms or multicellular communities have been a major issue as they cause resistance against antimicrobial agents and biofouling. To date, numerous biofilm-forming microorganisms have been identified, which have been shown to result in major effects including biofouling and biofilm-related infections. Quorum sensing (which describes the cell communication within biofilms) plays a vital role in the regulation of biofilm formation and its virulence. As such, elucidating the various mechanisms responsible for biofilm resistance (including quorum sensing) will assist in developing strategies to inhibit and control the formation of biofilms in nature. Employing biological control measures (such as the use of bioactive compounds) in targeting biofilms is of great interest since they naturally possess antimicrobial activity among other favorable attributes and can also possibly act as potent antibiofilm agents. As an effort to re-establish the current notion and understanding of biofilms, the present review discuss the stages involved in biofilm formation, the factors contributing to its development, the effects of biofilms in various industries, and the use of various bioactive compounds and their strategies in biofilm inhibition. |
| Databáze: | OpenAIRE |
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