Morphologic variations in the pineal gland of the albino rat after a chronic alcoholisation process
| Autor: | F Martinez-Soriano, Arantxa Blasco-Serra, J. Martínez-Salvador, Alfonso A. Valverde-Navarro, Amparo Ruiz-Torner |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Period (gene) Biology Pineal Parenchyma Pineal Gland 03 medical and health sciences Pineal gland 0302 clinical medicine Microscopy Electron Transmission Internal medicine medicine Animals Circadian rhythm Rats Wistar Ethanol Central Nervous System Depressants Cell Biology General Medicine Chronic alcohol Circadian Rhythm Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Ultrastructure 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Tissuecell. 51 |
| ISSN: | 1532-3072 |
| Popis: | We studied the effect of alcohol on the pineal gland of 48 male Wistar rats. Animals were divided into control and experimental groups. The experimental group underwent a previous progressive alcoholisation period with ethanol diluted in water at a concentration of 40%. Animals were sacrificed at 3, 6, 9 and 12 months, and the ultrastructure, karyometric indices, and number of synaptic bodies in the pineal gland were analysed. The results showed progressive morphologic alterations in the ethanol-treated animals, which culminated in fatty degeneration of the pineal parenchyma after 6 months. The karyometric indices decreased in both the central and peripheral areas compared with the control group. Moreover, the seasonal rhythmicity observed in the controls disappeared in the experimental groups, whose number of different populations of synaptic bodies (synaptic ribbons and synaptic spherules) considerably lowered with inversion of their normal seasonal rhythm. These results support that chronic alcoholisation leads to fatty degeneration of the pineal parenchyma, and a considerable alteration in nuclear functional rhythms and synaptic bodies. |
| Databáze: | OpenAIRE |
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