Progression of brain functional connectivity and frontal cognitive dysfunction in ALS
| Autor: | Vincenzo Silani, Elisa Canu, Davide Calderaro, Massimo Filippi, Veronica Castelnovo, Barbara Poletti, Federica Agosta, Silvia Basaia, Nilo Riva, Federica Solca |
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| Přispěvatelé: | Castelnovo, V., Canu, E., Calderaro, D., Riva, N., Poletti, B., Basaia, S., Solca, F., Silani, V., Filippi, M., Agosta, F. |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Longitudinal study Cognitive Neuroscience Audiology lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities lcsh:RC346-429 050105 experimental psychology rs-FC resting-state functional connectivity Functional connectivity 03 medical and health sciences 0302 clinical medicine Gyrus Humans Medicine Middle frontal gyrus Cognitive Dysfunction 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Resting-state fMRI Longitudinal Studies Amyotrophic lateral sclerosis IC independent component lcsh:Neurology. Diseases of the nervous system Core (anatomy) TAP Test of Attentional Performance Resting state fMRI MFG middle frontal gyrus business.industry Amyotrophic Lateral Sclerosis 05 social sciences Brain Regular Article rs-fMRI rs functional MRI Cognition Frontotemporal lobar degeneration medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology lcsh:R858-859.7 Fronto-connected networks Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 28, Iss, Pp 102509-(2020) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102509 |
| Popis: | Highlights • Frontal functional connectivity (FC) alterations in ALS emerge over six months. • The frontal FC alterations over time are related to executive dysfunction in ALS. • The middle frontal gyrus is a key area for the frontoparietal breakdown in ALS. • This study offers new potential markers for monitoring altered FC in ALS over time. Objective To investigate the progression of resting-state functional connectivity (rs-FC) changes in patients with amyotrophic lateral sclerosis (ALS) and their relationship with frontal cognitive alterations. Methods This is a multicentre, observational and longitudinal study. At baseline and after six months, 25 ALS patients underwent 3D T1-weighted MRI, resting-state functional MRI (rs-fMRI), and the computerized Test of Attentional Performance (TAP). Using independent component analysis, rs-FC changes of brain networks involving connections to frontal lobes and their relationship with baseline cognitive scores and cognitive changes over time were assessed. With a seed-based approach, rs-FC longitudinal changes of the middle frontal gyrus (MFG) were also explored. Results After six months, ALS patients showed an increased rs-FC of the left anterior cingulate, left middle frontal gyrus (MFG) and left superior frontal gyrus within the frontostriatal network, and of the left MFG, left supramarginal gyrus and right angular gyrus within the left frontoparietal network. Within the frontostriatal network, a worse baseline performance at TAP divided attention task was associated with an increased rs-FC over time in the left MFG and a worse baseline performance at the category fluency index was related with increased rs-FC over time in the left frontal superior gyrus. After six months, the seed-based rs-FC analysis of the MFG with the whole brain showed decreased rs-FC of the right MFG with frontoparietal regions in patients compared to controls. Conclusions Rs-FC changes in ALS patients progressed over time within the frontostriatal and the frontoparietal networks and are related to frontal-executive dysfunction. The MFG seems a potential core region in the framework of a frontoparietal functional breakdown, which is typical of frontotemporal lobar degeneration. These findings offer new potential markers for monitoring extra-motor progression in ALS. |
| Databáze: | OpenAIRE |
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