Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults
| Autor: | Evan T. Keller, Thomas C. Havighurst, Austin L. Shug, Stefan Gravenstein, Kit Mui Chiu, Raymond A. Daynes, Mary J. Schmidt |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Aging Energy metabolism Dehydroepiandrosterone Epiandrosterone Age and sex Levocarnitine chemistry.chemical_compound Dehydroepiandrosterone sulfate Sex Factors Internal medicine Carnitine polycyclic compounds medicine Humans skin and connective tissue diseases Aged Aged 80 and over business.industry Dehydroepiandrosterone Sulfate General Medicine Metabolism Middle Aged Endocrinology Cross-Sectional Studies chemistry Female Geriatrics and Gerontology business human activities hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Age and ageing. 28(2) |
| ISSN: | 0002-0729 |
| Popis: | Objectives: L-carnitine and dehydro-epiandrosterone (DHEA) independently promote mitochondrial energy metabolism. We therefore wondered if an age-related deficiency of L-carnitine or DHEA may account for the declining energy metabolism associated with age. Methods: we evaluated serum levels of L-carnitine and the sulphated derivative of DHEA (DHEAS) in cross-sectional study of 216 healthy adults, aged 20‐95. Results: serum DHEAS levels declined, while total carnitine levels increased with age (P < 0.0001). Total and free carnitine and DHEAS levels were lower in women than men (P < 0.0001). Esterified/free (E/F) carnitine (inversely related to carnitine availability) increased with age in both sexes (P = 0.012). Conclusion: reduced carnitine availability correlates with the age-related decline of DHEAS levels. These results are consistent with the hypothesis that decreased energy metabolism with age relates to DHEAS levels and carnitine availability. |
| Databáze: | OpenAIRE |
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