Remotely Programmed Deep Brain Stimulation of the Bilateral Subthalamic Nucleus for the Treatment of Primary Parkinson Disease: A Randomized Controlled Trial Investigating the Safety and Efficacy of a Novel Deep Brain Stimulation System
| Autor: | Wei Wang, Dianyou Li, Chencheng Zhang, Judith Gault, Yanyan Zhao, Ming Shao, Guo-dong Gao, Jian-min Liu, Kristina Zeljic, Bomin Sun |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Levodopa Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Disease law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Subthalamic Nucleus law Rating scale medicine Humans In patient Prospective Studies 030212 general & internal medicine Aged business.industry Outcome measures Parkinson Disease Middle Aged Telemedicine Electrodes Implanted nervous system diseases Surgery Subthalamic nucleus Treatment Outcome Female Neurology (clinical) business Wireless Technology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Stereotactic and Functional Neurosurgery. 95:174-182 |
| ISSN: | 1423-0372 1011-6125 |
| DOI: | 10.1159/000475765 |
| Popis: | Background: Deep brain stimulation (DBS) is the most commonly performed surgery for the debilitating symptoms of Parkinson disease (PD). However, DBS systems remain largely unaffordable to patients in developing countries, warranting the development of a safe, economically viable, and functionally comparable alternative. Objective: To investigate the efficacy and safety of wirelessly programmed DBS of bilateral subthalamic nucleus (STN) in patients with primary PD. Methods: Sixty-four patients with primary PD were randomly divided into test and control groups (1:1), where DBS was initiated at either 1 month or 3 months, respectively, after surgery. Safety and efficacy of the treatment were compared between on- and off-medication states 3 months after surgery. Outcome measures included analysis of Unified Parkinson's Disease Rating Scale (UPDRS) scores, duration of “on” periods, and daily equivalent doses of levodopa. All patients were followed up both 6 and 12 months after surgery. Results: Three months after surgery, significant decrease in the UPDRS motor scores were observed for the test group in the off-medication state (25.08 ± 1.00) versus the control group (4.20 ± 1.99). Conclusions: Bilateral wireless programming STN-DBS is safe and effective for patients with primary PD in whom medical management has failed to restore motor function. |
| Databáze: | OpenAIRE |
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