Brown adipose tissue activity controls triglyceride clearance
| Autor: | Michael G. Kaul, Heinz Hohenberg, Horst Weller, Alexander Bartelt, Oliver T. Bruns, Kersten Peldschus, Karoline Bruegelmann, Alexander Eychmüller, Peter Nielsen, Rudolph Reimer, Barbara Freund, Philip L.S.M. Gordts, Ulrich I. Tromsdorf, Harald Ittrich, Christian Waurisch, Martin Merkel, Joerg Heeren, F. Rinninger |
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| Rok vydání: | 2011 |
| Předmět: |
CD36 Antigens
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Lipoproteins Adipose tissue Hyperlipidemias Biology General Biochemistry Genetics and Molecular Biology Mice chemistry.chemical_compound Insulin resistance Adipose Tissue Brown Internal medicine Hyperlipidemia Brown adipose tissue medicine Animals Humans Obesity Triglycerides chemistry.chemical_classification Lipoprotein lipase Triglyceride Fatty acid General Medicine medicine.disease Cold Temperature Mice Inbred C57BL Lipoprotein Lipase Cholesterol Endocrinology medicine.anatomical_structure chemistry Insulin Resistance Body Temperature Regulation Lipoprotein |
| Zdroj: | Nature Medicine. 17:200-205 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/nm.2297 |
| Popis: | Elevated triglyceride levels often occur in obesity and can contribute to cardiovascular disease. Brown adipose tissue (BAT) is known to burn fat, and now Joerg Heeren and his colleagues show that BAT actively takes up triglycerides in cold conditions, suggesting a possible therapy to lower triglyceride levels in states of obesity. Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against cold1,2 and has recently been shown to be present in humans3,4,5. Triglyceride-rich lipoproteins (TRLs) transport lipids in the bloodstream, where the fatty acid moieties are liberated by the action of lipoprotein lipase (LPL)6. Peripheral organs such as muscle and adipose tissue take up the fatty acids, whereas the remaining cholesterol-rich remnant particles are cleared by the liver6. Elevated plasma triglyceride concentrations and prolonged circulation of cholesterol-rich remnants, especially in diabetic dyslipidemia, are risk factors for cardiovascular disease7,8,9,10,11. However, the precise biological role of BAT for TRL clearance remains unclear. Here we show that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice. Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and transmembrane receptor CD36. In pathophysiological settings, cold exposure corrected hyperlipidemia and improved deleterious effects of insulin resistance. In conclusion, BAT activity controls vascular lipoprotein homeostasis by inducing a metabolic program that boosts TRL turnover and channels lipids into BAT. Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans. |
| Databáze: | OpenAIRE |
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