In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine
| Autor: | Leandro de Oliveira Porfírio, Cochiran Pereira dos Santos, Victor Hugo Vitorino Sarmento, Elizabeth Ting, Guilherme Rodolfo Souza de Araujo, Rogéria De Souza Nunes, Luiz André Santos Silva, Ana Amélia M. Lira, Danielle Gomes Santana, Paula Ferreira Barbosa, Narendra Narain |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Surface Properties Skin Absorption Bioadhesive Dispersity 02 engineering and technology Methylcellulose Administration Cutaneous 01 natural sciences Polyvinyl alcohol chemistry.chemical_compound Colloid and Surface Chemistry 0103 physical sciences Animals Prodrugs Microemulsion Particle Size Rats Wistar Physical and Theoretical Chemistry Skin Transdermal chemistry.chemical_classification 010304 chemical physics Chemistry Surfaces and Interfaces General Medicine Polymer Permeation 021001 nanoscience & nanotechnology Propylene Glycol Rats Eucalyptus Oil Yield (chemistry) Emulsions 0210 nano-technology Gels Zidovudine Biotechnology Nuclear chemistry |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 188:110739 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2019.110739 |
| Popis: | This study aims to develop in situ microemulsion-gel (ME-Gel) obtained from hydroxypropyl methylcellulose (HPMC) films for transdermal administration of Zidovudine (AZT). Firstly, HPMC films containing propylene glycol (PG) and eucalyptus oil (EO) were obtained and characterized. Later, a pseudo-ternary phase diagram composed of water, EO, tween 80 and PG was obtained and one microemulsion (ME) with a similar proportion of the film components was obtained. ME was transformed in ME-Gel by the incorporation of HPMC. Finally, HPMC films were hydrated with Tween 80 solution to yield in situ ME-Gel and its effect on AZT skin permeation was compared with HPMC film hydrated with water (F5hyd). The results showed that the ME and ME-Gel presented a droplet size of 16.79 and 122.13 μm, respectively, polydispersity index (PDI) |
| Databáze: | OpenAIRE |
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