Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase
| Autor: | Munetake Kanda, Masaaki Suzuki, Yoichi Goto, Hiroshi Nonogi, Yutaka Harano, Shunichi Miyazaki, Satoshi Yasuda |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Type 2 diabetes Arginine Nitric oxide chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus Blood plasma medicine Humans biology Tumor Necrosis Factor-alpha business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Nitric oxide synthase Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Hyperglycemia biology.protein Female Endothelium Vascular Nitric Oxide Synthase Cardiology and Cardiovascular Medicine Asymmetric dimethylarginine business Diabetic Angiopathies |
| Zdroj: | European Heart Journal. 27:1159-1165 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehi876 |
| Popis: | Aims Vascular endothelium is a major organ involved in hyperglycaemia and is affected by plasma asymmetric dimethylarginine (ADMA). ADMA is an endogenous, competitive inhibitor of nitric oxide synthase and is induced by inflammatory cytokines of tumour necrosis factor (TNF)-α in vitro . We hypothesized that a tight glycaemic control may restore endothelial function in patients with type-2 diabetes mellitus (DM), in association with modulation of TNF-α and/or reduction of ADMA level. Methods and results In 24 patients with type-2 DM, the flow-mediated, endothelium-dependent dilation (FMD: %) of brachial arteries during reactive hyperaemia was determined by a high-resolution ultrasound method. Blood samples for glucose, cholesterol, TNF-α, and ADMA analyses were also collected from these patients after fasting. No significant glycaemic or FMD changes were observed in 10 patients receiving the conventional therapy. In 14 patients who were hospitalized and intensively treated, there was a significant decrease in glucose level after the treatment [from 190±55 to 117±21 (mean±SD) mg/dL, P |
| Databáze: | OpenAIRE |
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