Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response
| Autor: | Andor W. J. M. Glaudemans, Mike Sathekge, Alfred O. Ankrah, Rudi Dierckx |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
host defence QH301-705.5 medicine.drug_class Antimicrobial peptides INVASIVE PULMONARY ASPERGILLOSIS Inflammation Review Plant Science Monoclonal antibody 030218 nuclear medicine & medical imaging Microbiology WHITE BLOOD-CELLS 03 medical and health sciences 0302 clinical medicine POSITRON-EMISSION-TOMOGRAPHY INFLAMMATION Immunity medicine Radionuclide imaging Biology (General) F-18 LABELED FLUCONAZOLE Candida albicans Ecology Evolution Behavior and Systematics radionuclides ANTIGRANULOCYTE MONOCLONAL-ANTIBODY CANDIDA-ALBICANS invasive fungal infections biology Host (biology) Host defence RADIOIMMUNOTHERAPY biology.organism_classification ANTIMICROBIAL PEPTIDES FDG PET/CT PET 030220 oncology & carcinogenesis SPECT fungi medicine.symptom |
| Zdroj: | Journal of Fungi Journal of Fungi, Vol 7, Iss 407, p 407 (2021) |
| ISSN: | 2309-608X |
| DOI: | 10.3390/jof7060407 |
| Popis: | The human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides. Several important clinical applications have been found with radiolabelled biomolecules of inflammation. 18F-fluorodeoxyglucose is the tracer that has been most widely investigated in the host defence of fungi. This tracer has added value in the early detection of infection, in staging and visualising dissemination of infection, and in monitoring antifungal treatment. Radiolabelled antimicrobial peptides showed promising results, but large prospective studies in fungal infection are lacking. Other tracers have also been used in imaging events of the host response, such as the migration of white blood cells at sites of infection, nutritional immunity in iron metabolism, and radiolabelled monoclonal antibodies. Many tracers are still at the preclinical stage. Some tracers require further studies before translation into clinical use. The application of therapeutic radionuclides offers a very promising clinical application of these tracers in managing drug-resistant fungi. |
| Databáze: | OpenAIRE |
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