Angiogenic markers during preeclampsia: Are they associated with hypertension 1 year postpartum?
| Autor: | A.H. Jan Danser, Aveline M.J. Figaroa, Koen Verdonk, Daan Nieboer, Willy Visser, Anton H. van den Meiracker, Langeza Saleh, Hans Duvekot, Jeanine E. Roeters van Lennep, Rugina I. Neuman |
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| Přispěvatelé: | Internal Medicine, Obstetrics & Gynecology, Public Health |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Placental growth factor medicine.medical_specialty 030204 cardiovascular system & hematology Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Interquartile range Internal Medicine medicine Humans Prospective Studies Prospective cohort study Placenta Growth Factor Vascular Endothelial Growth Factor Receptor-1 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology Gestational age medicine.disease Blood pressure Hypertension embryonic structures Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Pregnancy Hypertension, 23, 116-122. Elsevier |
| ISSN: | 2210-7789 |
| DOI: | 10.1016/j.preghy.2020.11.011 |
| Popis: | Objectives Preeclampsia is associated with hypertension in later life, but the underlying pathophysiological mechanisms remain uncertain. We aimed to explore whether the angiogenic markers soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) measured in women with preeclampsia could be associated with hypertension 1 year after delivery. Methods This is a secondary analysis of a prospective cohort study, originally aimed to evaluate the use of sFlt-1/PlGF ratio to predict adverse outcome in women with (suspected) preeclampsia. Office blood pressure (BP) was evaluated at 1 year postpartum in women who had a confirmed diagnosis of preeclampsia within one week of biomarker measurement. Results Eighty women were included with a median (interquartile range) gestational age (GA) at biomarker measurement of 30 (27–33) weeks. Twenty-three (29%) women had hypertension 1 year postpartum. These women showed higher median SBP during their pregnancy and lower GA at PE diagnosis compared to women without hypertension. Median PlGF levels were lower in women with hypertension 1 year postpartum compared to women without hypertension (23 vs. 48 pg/mL, p = 0.017), while no differences in sFlt-1 or sFlt-1/PlGF ratio were observed. Multivariable analysis adjusted for GA did not show significant association between PlGF (nor sFlt-1, sFlt-1/PlGF ratio) and hypertension 1 year postpartum (OR [95% CI] 0.9 [0.2–4.4], p = 0.97). Conclusion Our data indicate that sFlt-1, PlGF or their ratio measured during pregnancy are not suitable for the prediction of hypertension 1 year postpartum and hence guiding follow-up of women with previous preeclampsia. |
| Databáze: | OpenAIRE |
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