Timolol increased retrobulbar flow velocities in untreated glaucoma eyes but not in ocular hypertension
| Autor: | Alon Harris, Anders Heijl, Ingar C. Bergstrand, Per Wollmer, Flemming Hansen |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Central retinal artery genetic structures Open angle glaucoma Retinal Artery Adrenergic beta-Antagonists Diastole Timolol Glaucoma Ocular hypertension Blood Pressure Ophthalmic Artery Ophthalmology medicine.artery Medicine Homeostasis Humans Ultrasonography Doppler Color Intraocular Pressure Aged Aged 80 and over business.industry Blood flow Middle Aged medicine.disease eye diseases Ophthalmic artery Female Ocular Hypertension sense organs Ophthalmic Solutions business Blood Flow Velocity Glaucoma Open-Angle medicine.drug |
| Zdroj: | Acta ophthalmologica Scandinavica. 79(5) |
| ISSN: | 1395-3907 |
| Popis: | PURPOSE: To investigate retrobulbar blood flow velocities and the effects of topical timolol treatment in eyes with newly detected, previously untreated open angle glaucoma or ocular hypertension. METHODS: Fifteen eyes with open angle glaucoma (OAG) and 12 eyes with ocular hypertension (OH), in the same number of patients, all untreated and newly detected, were examined with colour Doppler imaging of retrobulbar vessels before and after 1 month of topical timolol treatment (0.5% Timoptic BID). RESULTS: Baseline central retinal artery end diastolic velocity was lower (48%, p=0.0002) and resistive index higher (7.6%, p=0.018) in the OAG group than in the OH group. In the glaucoma group mean end diastolic velocity increased by 41%, (p=0.006) while resistive index decreased by 5.8%, (p=0.02) on treatment, while no significant changes were seen in the OH group. Blood flow velocities in the ophthalmic artery did not change with treatment. Baseline IOP and IOP reduction did not differ between OAG and OH group. CONCLUSION: Peripheral resistance to blood flow was found to be increased in untreated glaucoma eyes as compared to a similar group of eyes with ocular hypertension. Timolol treatment diminished resistance significantly in the glaucoma group, but not in the ocular hypertension group. Thus the two groups responded differently to timolol treatment. The reaction to IOP lowering treatment could indicate defective autoregulation in the glaucoma group. |
| Databáze: | OpenAIRE |
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