Alpha emitting nuclides for targeted therapy
| Autor: | Cathy S. Cutler, Vanessa A. Sanders, Mohammed Z. Rahman, Lynn C. Francesconi, Jasmine L. Hatcher-Lamarre |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_treatment Normal tissue Alpha (ethology) Article 030218 nuclear medicine & medical imaging Targeted therapy 03 medical and health sciences 0302 clinical medicine In vivo medicine Animals Humans Radiology Nuclear Medicine and imaging Nuclide chemistry.chemical_classification Radiochemistry Isotope Biomolecule Alpha particle Alpha Particles chemistry Isotope Labeling 030220 oncology & carcinogenesis Biophysics Molecular Medicine |
| Zdroj: | Nucl Med Biol |
| ISSN: | 0969-8051 |
| Popis: | Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives suitable for coordination with larger biomolecules, and additionally actinium-225 has potential to serve as an in vivo generator. In this review, the authors will discuss the production, purification, labeling reactions, and biological studies of actinium-225 and thorium-227 complexes and clinical studies. |
| Databáze: | OpenAIRE |
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