Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study
| Autor: | Peigang Cao, Haoyu Lu, Yang Hu, Shizheng Qiu, Yu Guo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty causality QH301-705.5 Genome-wide association study Single-nucleotide polymorphism Disease Gastroenterology 03 medical and health sciences Cell and Developmental Biology 0302 clinical medicine Internal medicine NAFLD Mendelian randomization medicine GWAS Biology (General) Original Research business.industry Fatty liver nutritional and metabolic diseases Correction Cell Biology medicine.disease Causality 030104 developmental biology Etiology mendelian randomization 030211 gastroenterology & hepatology Observational study hypothyroidism business Developmental Biology SNPs |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| ISSN: | 2296-634X |
| Popis: | The etiology of non-alcoholic fatty liver disease (NAFLD) involves complex interaction of genetic and environmental factors. A large number of observational studies have shown that hypothyroidism contributes to a high risk of NAFLD. However, the exact causality is still unknown. Due to the progress of genome-wide association study (GWAS) and the discovery of Mendelian randomization (MR), it is possible to explore the causality between the two diseases. In this study, in order to research into the influence of intermediate phenotypes on outcome, nine independent genetic variants of hypothyroidism obtained from the GWAS were used as instrumental variables (IVs) to perform MR analysis on NAFLD. Since there was no heterogeneity between IVs (P= 0.70), a fixed-effects model was used. The correlation between hypothyroidism and NAFLD was evaluated by using inverse-variance weighted (IVW) method and weighted median method. Then the sensitivity test was analyzed. The results showed that there was a high OR (1.7578; 95%CI 1.1897–2.5970;P= 0.0046) and a low intercept (−0.095;P= 0.431). None of the genetic variants drove the overall result (P< 0.01). Simply, we proved for the first time that the risk of NAFLD increases significantly on patients with hypothyroidism. Furthermore, we explained possible causes of NAFLD caused by hypothyroidism. |
| Databáze: | OpenAIRE |
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