Highly Enantioselective Synthesis of 3-Hydroxy-2-methylpropanoic Acid Esters Through Ruthenium-SYNPHOS®-Catalyzed Hydrogenation: Useful Building Blocks for the Synthetic Community

Autor:	Jean-Pierre Genêt, Séverine Jeulin, Tahar Ayad, Virginie Ratovelomanana-Vidal
Rok vydání:	2007
Předmět:	Chemistry Asymmetric hydrogenation Enantioselective synthesis 3-hydroxy-2-methylpropanoic acid Noyori asymmetric hydrogenation chemistry.chemical_element General Chemistry General Medicine Catalysis Ruthenium chemistry.chemical_compound Organic chemistry Enantiomer Roche ester
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200746046
Popis:	Both enantiomers of 3-hydroxy-2-methylpropanoic acid tert-butyl ester were prepared with high enantioselectivity (up to 94 %) through a ruthenium-SYNPHOS®-promoted asymmetric hydrogenation reaction using an atom-economic transformation from simple and inexpensive precursors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4c60f3b8c6ac93170e997941f20a3c https://doi.org/10.1002/chin.200746046 Zobrazit plný text záznamu Plný text